Snood
Forum Junior
Topics: 11
Posts: 55
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So, whats the deal, what can we legally say about our tests when we leave?
Anyways, this is unrelated to the NBME -
An alcoholic experiences
a. pharmacodynamic tolerance
b. pharmacokinetic tolerance
(after drinking a lot what's kind of tolerance happens?) :?
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| Snood
Forum Junior
Topics: 11
Posts: 55
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I think acutely it is pharmacodynamic tolerance, like when I take benzodiazepines(eg.), and perhaps long term we also develop pharmacokinetic tolerance by upregulating our synthesis of liver enzymes.
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| Snood
Forum Junior
Topics: 11
Posts: 55
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I hate NBME!!!
anyways here is this question. ugh! every time I pick a different answer. Not anymore!
Tolerance and Physical Dependence
Persons who drink large amounts of alcohol repetitively over time become tolerant to its effects (tolerance also occurs with other CNS depressants--eg, barbiturates, meprobamate); later doses do not have the same intoxicating effect as earlier ones. Tolerance is caused by adaptational changes of CNS cells (called cellular or pharmacodynamic tolerance). Persons tolerant of alcohol may have an incredibly high BAC; a few have survived a BAC of > 700 mg/dL (> 152 mmol/L). However, ethanol tolerance is incomplete, and drinkers always manifest some degree of intoxication and impairment with a high enough dose. In tolerant animals, the lethal dose is only minimally higher than an intoxicating dose. Persons may die of respiratory depression secondary to alcohol overdose, even in the presence of tolerance. The physical dependence accompanying tolerance is profound, and withdrawal produces adverse effects that may lead to death. Those tolerant of alcohol are cross-tolerant to many other CNS depressants (eg, barbiturates, nonbarbiturate hypnotics, benzodiazepines).
http://www.merck.com/mrkshared/mmanual/section15/...
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