smitha
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Posts: 236
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HEMATOLOGY.
PT…..WARFARIN….EXTRINSIC SYSTEM…..2,5,7,10……..VIT.K
PTT…..HEPARIN……INTRINSIC SYSTEM…..All factors xcept 7 &13.
BLEEDING DISORDERS……A)……….
1.QUANTITATIVE
2.QUALITATIVE……CONGENITAL & ACQUIRED.
CONGENITAL…………1.Bernard—Souli er’s ds.----defect of platelet adhesion
2.Glanzmann’s thrombasthenia….defect of platelet aggregation.
B)……….
1. PLATELET ABNORMALITIES/MICROHEMORRHAGES:
Mucous membrane bleeding, petechiae, purpura, prolonged BT
CAUSES: ITP(antiplatelet abs, increased mega karyocytes)
TTP(Schistocytes)
Drugs
DIC(rise in FDPs)
2. COAGULATION ABNORMALITIES/MACROHEMORRHAGES
Hemarthroses, easy bruising,rise in PT and /or PTT
CAUSES: HemophiliaA(factor 8 deficiency)
Hemophilia B(factor 9 deficiency)
Von Willebrand’s ds.(VW ag. Deficiency)
BT PTT PT PC
1.Qualitative & vascular bleedings……. R --- -----
2.Quantitative thrombocytopenia R --- --- L
3.Hemophilia A --- R --- ---- 4.Hemophilia B -- R --- ---
5. Von willebrand’s ds…. R R --- ---
6. DIC R R R ---
7.LIVER DS. -- R R ---
BT....bleeding time; PT---prothrombin time; PTT---partial thromboplastin time;PC--platelet count; R---RAISED; L---LOW
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| smitha
Forum Elite
Topics: 53
Posts: 236
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sorry guys.........the table wasn't good........so am repeating in a different pattern....... 
1.Qualitative & vascular bleedings------- BT------R;OTHERS NORMAL
2.Quantitative thrombocytopenia----BT---R, PC--L; OTHERS NORMAL
3.Hemophilia A -----PTT---R;OTHERS NORMAL
4.Hemophilia B -----PTT---R;OTHERS NORMAL
5. Von willebrand’s ds-----PTT AND BT---R; OTHERS NORMAL
6. DIC-----PT, PTT, BT -------R;
7.LIVER DS. -----PT, PTT------R;
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