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Kaplan Qbank USMLE



Author2 Posts
  #1

A sample of purified oligopeptide sequence was treated with cyanogen bromide. The original sequence is NH3—Gly-Arg-Phe-Lys-Met-Asp-Tyr-Ala-Arg-Met-Glu—COO— Which of the following is the appropriate cleavage product?

A. Gly-Arg-Phe-Lys-Met/Asp-Tyr-Ala-Arg-Met/Glu

B. Gly-Arg-Phe/Lys-Met-Asp-Tyr/Ala-Arg-Met-Glu

C. Gly-Arg/Phe-Lys/Met-Asp-Tyr-Ala-Arg-Met-Glu

D. Gly/Arg-Phe-Lys-Met-Asp-Tyr-Ala/Arg-Met-Glu

E. Gly/Arg-Phe-Lys-Met-Asp-Tyr-Ala-Arg-Met-Glu

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  #2

the ans is (A). Cyanogen bromide cleaves peptide bonds at the carboxyl terminal side of Methionines.







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