krishie
Forum Senior
Topics: 17
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Hi,
I just came across this question,in which a patient with magnesium deficiency ends up with functional hypoparathyroidism.Could anyone please tell me what happens to bone density in this situation?
Krishie.
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krish
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| Kazem
Forum Elite
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The classic sign of severe hypomagnesemia (<1.2 mg/dL) is hypocalcemia. The mechanism is multifactorial. Parathyroid gland function is abnormal, largely because of impaired release of PTH. Impaired magnesium-dependent adenyl cyclase generation of cAMP mediates the decreased release of PTH. Skeletal resistance to this hormone in magnesium deficiency has also been implicated.
Hypomagnesemia also alters the normal heteroionic exchange of calcium and magnesium at the bone surface, leading to an increased bone release of magnesium ions in exchange for an increased skeletal uptake of calcium from the serum.
The H+-K+-ATPase pump in the cells of the periosteum is magnesium dependent, which may lead to decreased pH in the bone extracellular fluid and increased demineralization. In addition, the formation of calcitriol involves a magnesium-dependent hydroxylase enzyme, and concentrations are reduced in magnesium deficiency, possibly affecting calcium reabsorption. So I guess bone density decreases in hypomagnesemia.
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| krishie
Forum Senior
Topics: 17
Posts: 128
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Thank u so much,kazem!That was a great explanation.
Krishie
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krish
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| Kazem
Forum Elite
Topics: 76
Posts: 296
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most welcome :wink:
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