simi
Forum Elite
Topics: 53
Posts: 361
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Hello friends,
In the kaplan ,it is given that aldosterone decreases in 17 hydroxylase deficeincy.
can anyone explain that to me please??? :roll:
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| mjl1717
Forum Hero
Topics: 959
Posts: 5,467
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I think it has to do with these reasons:
1)Excess ACTH causes adrenal hyperplasia.
2)**Paradoxically 11 deoxycorticosterone just becomes more profound.
3)A rise in BP has been caused/so there is less renin and angiotensin II
(remember this is a potent stimulator of aldosterone)
4)Eventuallly aldosterone is decreased and you have shut down of the zona glomerulosa!
Hope this heps
5)Addendum-Even easier:
Increase BP :arrow: decrease Renin :arrow: decreaseAngioII :arrow: decrease aldosterone
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