mjl1717
Forum Hero
Topics: 959
Posts: 5,467
|
Under normal conitions, receptors are not saturated: that is extra receptors exist. Normally the # of receptors is not rate limiting for drug or hormone action action. Plasma conc. of free drug or hormone is usually indicative of activity.
___________________
Smell the coffee! "Is That an Osler move??"
|
| kmp
Forum Elite
Topics: 38
Posts: 311
|
Thanks for your reply mjl1717.
In FA 2004 (pharmac section page 290 ) there is a graph in pharmacodynamics for the spare receptors. Can u please tell me what is EC50 and Kd.
thnanks .
|
| mjl1717
Forum Hero
Topics: 959
Posts: 5,467
|
I have the 2003 Kaplan:
1)I think EC50 is the effective dose or conc. in 50% of a population
2)Kd, I believe is a disassociation constant-is the free drug conc. at which 50% of the corresponding binding site on the protein is saturated.
Addendum:some math
{drug protein complex}/{unbound drug}times{protein}=k1/k2=Kd
hope this helps
___________________
Smell the coffee! "Is That an Osler move??"
|
| kmp
Forum Elite
Topics: 38
Posts: 311
|
thank you mjl1717 for your reply.
|
|
| |
| | | | |
Similar forum topics