 |  A 20-year-old student, who was previousl
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| Author | 9 Posts |
usmlebuzz
Forum Elite
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A 20-year-old student, who was previously HIV negative, has unprotected sexual relations with a person whom he later finds out is HIV positive. One month after the unprotected sexual encounter, the now HIV-infected student volunteers for a research study, in which he undergoes extensive blood tests. What would you expect to see in the patient's lab tests?
A. Decreased number of CD4 count and increased p24 antigen
B. Increased anti-gp120 antigen
C. Increased anti-p24 antigen
D. Normal CD4 count and increased p24 antigen
E. Normal CD4 count and undetectable p24 antigen
ans is A but I thought that cd4 count remains normal early in HIV??????
:roll:
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| rajeev
Forum Junior
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yeah .. i woulda picked d ....
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| Yulia
Forum Elite
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I'd say you're right rajeev. CD4 count can't be all that low. Unless you know what it was right before the "accident" you will not know it's any different.
Here, look at this:
I saw this question about 38 y.o. caucasian male who was HIV positive for 15 years, never did any antiretroviral prophylaxis and never actually got sick and his CD4 count is still normal and is not going anywhere. So, they investigated that and found a protecting mutation. The question is: where 's the mutation??
a. CCR5
b. CXCR1
c. CD4
d. CD8
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| rajeev
Forum Junior
Topics: 5
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. ... im gonna close my eyes and answer this one... CCR 5 !
my sister is working on a vaccine for combatting CCR 5 ....thats all she's talking abt even in her sleep ...CCR5 
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| Yulia
Forum Elite
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wow!!! I am so impressed!!!
I had no idea and immediately jumped on cd4  and that of course was wrong. but i'm glad i saw it - learned something new.
and mutaion in cxcr1 is "the bad guy" it has been linked to rapid progression of hiv infection in homozygous pts.
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| rajeev
Forum Junior
Topics: 5
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whoa ...look who's jumping Qns now ... quick qn .. i feel the sudden urge to buy nms 850 qns and do it ...
is it worth it ?
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| usmlebuzz
Forum Elite
Topics: 93
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thanks, for the reply yulia and rajeev . I would have picked up CD4 too .
the question setters are so smart ,they know how to tempt us to the wrong choice #-o
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| waqastariq
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a
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| spjokes
Forum Senior
Topics: 3
Posts: 88
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ANS: A. CCR5 mutation. Robbins p 249 e 7
CCR5 mutation (Homozygous) is protective . seen in 1% of white americans
Heterozygous mutation is not protective against AIDS but the onset of the disease is somewhat delayed. seen in 18% - 20% of white americans.
Homozygous mutation is rare in African/ East asian population.
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