katzung
Forum Guru
Topics: 74
Posts: 624
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IS DNA TOPOISOMERASE -1 SAME AS HELICASE,
I KNOW DNZ TOPOISOMERASE -2 IS ALSO CALLED DNA GYRASE
SO
IS DNA TOPOISOMERASE -1 SAME AS HELICASE?
:?:
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| boo
Forum Senior
Topics: 4
Posts: 49
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no they are not the same .
dna a protien : recognises AT rich bases pairs in the origin of replication
single strand binding protien: keeps the two strands seperated
helicase: the only one requiring ATP keeps the replication fork intact during replication preventing reanneling of strands
THESE ENZYMES ARE REQUIRED FOR REPLICATION.
TOPOISOMERASES : these correct the supercoiling caused during replication of the strand beyond the replication fork.
TOPOISOMERASE 1 ; has both ligases and endonuclease activity
TOPOISOMERASE 2 : IS DNA GYRASE ( IN BACTERIA) on which quinolones act.
hope this helps
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