anatomy
Forum Guru
Topics: 101
Posts: 423
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To achieve a loading dose of a drug where the volume of distribution of drug is 35L and clearance rate is 70 ml/min and desired dose is 3.5 mg/L, one should administer how many mg of drug initially?
a) 70 mg
b) 122 mg
c) 175 mg
d) 200 mg
e) 225 mg
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| kmp
Forum Elite
Topics: 38
Posts: 311
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Is it 122mg
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| anatomy
Forum Guru
Topics: 101
Posts: 423
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u r right.
here is the calculation
LD = Vd x Cp(ss)
LD = 35L x 3.5 mg/L
LD = 122 mg
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