beta blocker
Forum Newbie
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hi there
Help me in this concept.
When we eat fat in our diet,It is in the form of fatty acid.We store fat in the form of triglyceride.So fatty acid has to join with glycerol phosphate to make triglyceride.This is done in the liver where we have glycerol kinase to add phosphate to glycerol as adipose doesnot have G-kinase.Now when the triglycerides are made they are carried by chylomicrons to the adipose tissue for storage.
The other source of fat storage is excessive glucose after glycogen is saturated.The glucose is converted to fatty acid in the liver and then stored in the triglycerides of VLDL in blood.VLDL is sent to adipose tissue where TG are broken down and resynthesized and hence stored.
When we want to break TG,we need lipoprotien lipase in adipose tissue.which converts it to fatty acid and glycerol.The glycerol goes in the liver where G-kinase makes glycerol phosphate and enters metabolic pathways.
If I am wrong somewhere,plz correct me.I will be obliged.
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| skylark
Forum Newbie
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Posts: 21
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fat in diet comes in different forms. after digestion the fatty acids enter the enterocit, where they are again coverted to TAG, phospolipids and cholesterol esters, all parts of the chylomicrons. these reach the limph and then the blood where they distribute TAG to different tissues especially to the adipose and the muscle, indeed using lipoprotein lipase, which release the fatty acids and the glycerol. the latter will reach the liver where it will be used in TAG syntase or in gluconeogenesis/glycolysis, after the action of its kinase.
the chylomicron remnants are taken up by the liver also and further processed.
synthesis of TAG occurs both in the liver, lactating mammary glands and the adipose tissue to a lesser extent. VLDL carries de novo fatty acids from liver to different tissues, using lipoprotein lipase thru the apo CII.
the adipose can also synthetise TAG from fatty acid CoA and the glycerol phosphate, its unique source for the latter being the glycolytic pathway, while liver has the additional kinase one.
i hope this responds to at least part of your question
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| sr
Forum Newbie
Topics: 1
Posts: 19
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tag is the same as tg, right? i learned it as tg, but i believe my professor mentioned tag as the newer name. triglyceride vs. triacylglycerol???
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Los Angeles, CA, USA.
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