prep4usmle
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This thread can be used to post short review notes for Pharmacology.
Regards!
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| mjl1717
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Think of: (The original prototype was Zidovudine-AZT) also for starters
think of these as very weird Einstein formulas like:{inh. reverse trancriptase}
ddI--------------ddC-----------d4T-------------3TC------------abc
respectively:
didanosine---zalcitabine---stauvudine---lamivudine---abacavir
Sorry guys no pneumonic here, just dig in Deep 8)
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| mjl1717
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I work at a correctional institution/had a lecture today:
Efavirenz makes HIV prophalaxis much better by making the dosage easier
and hopefuly increasing compliance.
The name was mentioned numerous times.
As i remember a reasonable regimen could be ZDV or 3TC + EFAVIRENZ
+ a "new" (protease inh.) I believe its Taquinavir( I know it begins with a T
If nothing else remember my pneumonic NED for the NNRTIs
Nevaripine, Efavirenz, Delaviradine.
Unfortunately HIV prophylaxis has numerous names and is constantly changing!
NNRTI's do not require metabolic activation.
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| KEROCHI
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Clinical Uses of Dopamine
low dose- increase renal blood flow
mod. dose- increase heart contractility & rate
high dose- increase BP, rate & contraction
decrease renal blood flow
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| KEROCHI
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Epinephrine(a1, a2,B1,B2)
low dose(beta-like)- inc. HR, & small dec. in mean BP
high dose (alpha-like)- inc. PVR, inc. diastolic pressure
-inc. mean BP elicits reflex bradycardia
other actions: bronchodilation, inc. liver glycogenolysis
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| KEROCHI
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drug interactions:
PI(RITONAVIR)- inhibits major P450 -inc. effects of
dronabinol, erythromycin, ketoconazole
rifampin
H2 antagonist CIMETIDINE- inhibits P450- increase effects
of Quinidine, phenytoin, TCA's,
warfarin
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| KEROCHI
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drug interactions:
PPI(OMEPRAZOLE) inhibit P450-decrease elimination of Diazepam,
Phenytoin & Warfarin
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| Agrada
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Never give ketoconazole to patient taking astemizole (anti-histamine) why?
Because Ketoconazole inhibits liver metabolism of anti-histamines and leading to increase their blood concentration that can result in lethal cardiac arrhythmias
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| drpawan
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does any bodyknowabout fexofenidine in detail
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| DrVirgo
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This concept will help with a lot of the ANS tracings:
alpha 1--> VC--> Inc. TPR--> inc BP--> Reflex Bradycardia
beta 2--> VD--> Dec. TPR--> dec BP-->Reflex Tachycardia
beta 1--> Inc HR, Inc Pulse Pressure
Musc 2--> Dec. HR
Musc 3 -->VD --> Dec TPR--> Dec. MAP--> Reflex Tachycardia
Blood vessels have Alpha 1 and M3 Receptors but are ONLY innervated by SANS, NOT by PANS, so the drugs that can affect it are sympathetic agonists/blockers, and DIRECT acting drugs on Muscarinic receptors like Ach, but NOT Indirect acting drugs such as AchE-Inhibitors because those type of drugs work at the synapse, and there is NO PANS innervation of blood vessels.
Drugs with Alpha 1: Phenylephrine, Methoxamine, Epi, Norepi
Drugs with Beta 2: Metaproterenol, Albuterol, Terbutaline, Isoproterenol
Drugs with Beta 1: Isoproterenol, Epi, Norepi, Dobutamine
Drugs with Musc 2: Ach, Bethanechol, Carbachol, Pilocarpine, and AchE-Inhibitors
Ganglionic blockers will prevent the Reflex brady or tachycardia. (see above)
For drugs with dual action where there is change in Heart rate due to a reflex AND direct effects on the heart, giving a ganglionic blocker will BLOCK the reflex, buy you will still be able to see the DIRECT effects on the heart.
eg. Giving Norepi with a Ganglionic Blocker:
Norepi: alpha 1--VC--Inc. TPR --Inc MAP---Reflex Bradycardia BLOCKED!
BUT: beta 1---Inc. HR STILL PRESENT.
If anyone has any more hints to add, please do! 
Edited by DrVirgo on 03/10/06 - 05:52 PM
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| mjl1717
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Dr Virgo -what you're doing is deep and we appreciate it. {I think you mean metaproterenol for B2 agonist} {I find this part takes a lot of synthesizing, cognition, fusion, and extrapolating and whats agonizing or inhibiting and blocking- buddy.} Ill return still at work  .
Edited by mjl1717 on 03/10/06 - 03:38 PM
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| DrVirgo
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mjl,
Thanks for reading and catching that! I corrected it above in my post.
I will update this post as I think of more helpful hints, so check back later this week, and also try some of the questions I posted in the pharm forum.
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| gpsbrar
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Fexofenadine. Antihistaminic product (5HT1 antagonist). Used for allergies, idiopathic urticaria. recommended dose is 60mg B.D> or 180 mg O.D.
drpawan wrote: does any bodyknowabout fexofenidine in detail
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| mjl1717
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gpsbrar wrote:
Fexofenadine. Antihistaminic product (5HT1 antagonist). Used for allergies, idiopathic urticaria. recommended dose is 60mg B.D> or 180 mg O.D.
basically you got it. its a 3rd gen. nonsedating antihistamine that prevents a wheal and flare reaction. As I remember its now OTC and known as Allegra.
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| DrVirgo
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Level 5 Agents of Emesis:
Cisplatin
Carmustine
Cyclophosphamide
Dacarbazine
Lomustine
Mechlormethamine
Streptozocin
(additions to the list are welcome!)
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| study_ing
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1.yellow green halos in the visual field..tioxicity of
2. doc for arrythmias following attempted cardioversion
3.doc for av nodal arrythmias with half life of lesss than 30 sec
1.digoxin
2.lidocaine
3. adenosine
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| study_ing
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1.yellow green halos in the visual field..tioxicity of
2. doc for arrythmias following attempted cardioversion
3.doc for av nodal arrythmias with half life of lesss than 30 sec<?
1.digoxin
2.lidocaine
3. adenosine
4. why is digoxin contraindicated in WPW syndrome?
4. coz it wud increase the chances of conduction down th aberrant pathway and hence increase Ventricular rate
5. which drug needs prior digitilization prior to administration and why?
6.Which drugs are contraindicated in WPW?
5.well the answer is quinidine. it has antimuscarinic side effects which can increase hr and tachycardia. also alpha block--vasodilation--reflex tachy
hence need initial digitalization to slow av conduction
6. drugs which increase the refractory period in the normal av conduction pathway more are likely to INCREASE ventricular rate in WPW. this is because conduction will now occur along the aberrant pathway
7.hmm the question is wha twud u give in WPW?
8.and btw is there a problem using using digoxin and quinidine together?
8. yes...
VERy AMbitious QUeen
interacts with Digoxin
VErapamil, AMiodarone, QUinidine inrease digoxin levels hence chance of toxicity
Drugs contraindicated in WPW syndrome=digitalis,Ca channel blockers...
and Beta Blockers
7.Treatment WPW: quinidine
9. can amiodarone be used for acute treatment of palpitations due to arrythmia?
we dont use amiodarone for acute management as it duz not have an immediate onset of axn.
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| farroos
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hello guys h r u?? can anybody help me finding some review topics for pharmacology like cards and for pathology u would help me guys alot
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| bobby123
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Ah, you know what review program has a really good explanation of Pharmacology is Score95.com.
Cheers!!!
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| malcomxox
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gr8 work keep it up
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| drkash
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aDENOsine
for nodal(NODE) arrhythmias
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