Mars-Aris
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what's the underlying mechanism of constipation seen in hypothyroidism
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| mjl1717
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My hypothesis- If the overall metabolism(BMR) is inhibited, the functioning of the parasympathetic nervous system will be diminished. comments
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| Kazem
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I like Mjl1717's way of thinking.
I agree.
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| Mars-Aris
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i think that it has to do with the amount of b-receptors in GI
consider that T4 increases synthesis of b receptors. that why you see symptoms like tahycardia &palpitations in hyperthyroidism
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| kmp
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Mars -Aris is it not that GI glands are innervated by parasympathetic?
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| mjl1717
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I was waiting for someone to say that! /The way I remember it is "Housekeeping-Parasympathetic"
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| Mars-Aris
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sorry this was my terrible mistake :oops: a 'type error - actually i entered the forum to correct b/c suddenly came to my mind what i wrote
but you ve already noticed the mistake
of course parasympathetic increases GI motility & secretions :idea:
:oops:
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| Mars-Aris
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thinking more about the particular mechanism :
T4 acts intracellular in the nucleus (like steroid hormones) might interfere with synthesis/transcription of pumps responsible for Na exchange
BTW this is an open discussion (i am still looking for the answer) and what i write is some thoughts... :roll:
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