phuluong2k
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Why Folate & Vit B12 deficiency cause low transketolase activity ?
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| Mars-Aris
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transketolase is an important enzyme for HMP shunt.--> HMP shunt is useful for Ribose 5P synthesis and therefore for nucleotides -->
little synthesis of DNA in folate & Vit B12 def --> plenty of ribose 5P (unused) that leads to decreased transketolase activity
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| phuluong2k
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Thank for your answer
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| Mars-Aris
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is that correct ??
it is the only mechanism that i could think...
nice Q 
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| mjl1717
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Mars I like the reasoning:
But I also reflexively think of low transketolase activity with Thiamine
(B1) deficiency.
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| phuluong2k
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Thiamine is a cofactors of transketolase, so in thiamine deficiency will decrease the transketolase activity
In Vit B12 & Folate deficiency there is a low transketolase activity ( I see in Step 1 simulated question, but they don't tell the mechanism )
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