Snood
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Question:
A father comes to you, asking what percentage chance is there that his baby will have schizophrenia if the following is known
- He does not have schizophrenia, nor does anyone in his family, His wife is 29 years old & she has a monozygotic twin with schizophrenia. She however does not have schizophrenia.
What is the chance that their child will have schizophrenia
a. 1%
b. 10 %
c. 50 %
d. 99%
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its 50%!!!!!!
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| Snood
Forum Junior
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and neither of her parents have it?
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| Snood
Forum Junior
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Both parents of the Child are normal.
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monozygotic sibling has it....so it can be 50%
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| adeelmd
Forum Elite
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the prevlance for schizophrenia is 1% if that helps. Since it is a multifactorial inheritance disease, I don't think you can apply those genetic box here....
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| DiaHuq
Forum Elite
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isn't there a 12% risk in case of a first degree relative?
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| bozhenka
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more than 1% and less then 10%
10% is a right answer - I think :-)
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| mjl1717
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Playing with #s Ill say 10% Ill try to return with a formula.
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| Snood
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Im thinking it might be 1% like adeelmd said because its multifactorial inheritance & we cant use a genetic box. I think maybe they through in the other information as a distractor?
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| mjl1717
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The lifetime prevalence of schizo. in the U.S. is 1% so 50% and 10% may be waaaaaaaaaaaay off!
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Smell the coffee! "Is That an Osler move??"
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| mjl1717
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The lifetime prevalence of schizo. in the U.S. is 1% so 50% and 10% may be waaaaaaaaaaaay off!
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Smell the coffee! "Is That an Osler move??"
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| DiaHuq
Forum Elite
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in the kaplan live lectures and BRS,Barbara Fadem said that there is 1%risk of developing schizophrenia in the general population but if you have a 1st degree relative the risk increases to 12% if a first degree relative is diagnosed with schizophrenia.(parent,sibling,or dizygotic twin).
The monozygotic twin of a schizophrenic person has a 50% risk.
so it seems as if it should be 5-6%
the chance that the mother develops is 1/2 and the chance the son develops it if the mother develops is 1/12 so the chance of both happening should be 1/24?
right? or did I stretch that a little far?
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| Snood
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Well, I think since the Mom & father are 30 they are over the usual age to get it, so they are considered normies.
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| olena_r
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This is multifactorial inheritance.You can't figure it out from Mendelian laws. In general population the risk is 1%. The risk of schizofrenia in siblings is 8% . So, I d go with the closest which is 10%
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| drk1980
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there is only 1 other option left! anyone?
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| msyamp
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will go with 10%. no mention what kind of brought up. if you have a
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| sturge_weber
Forum Guru
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i too go with 10%. the next born child shares half of the genes with the child having schizophrenia, so ... the only thing is that noone in the family ever had the disease, so ...that is a bit confusing
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| msyamp
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not like halg genes
but
http://img251.imageshack.us/my.php?image=risk0ga....
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