Mars-Aris
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after 6 months of drug therapy a patient develops HTN and creatinuria without proteinuria.A biopsy shows ischemic damage to glomeruli and some tubular damage responsible drug ?
a) penicillin G
b) gentamicin
c) cyclosporine
d) naproxen
e) cyclophosphamide
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| sanz
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Naproxen
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| mjl1717
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I 'll go with gentamicin
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| whereami
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Cyclo?
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| Mars-Aris
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its cyclosporine it causes nephrotoxicity & hypertension
why not the others :
penicillin would cause acute hypersensitivite interstitial nephritis
gentamicin causes toxic ATN but that would be acute too & it would involve the tubule mainly - gentamicin --> myeloid bodies in PCT cells-
naproxen may cause chronic analgesic nephropathy but that would first manifest as papillary necorsis
cyclophosphamide causes cyctitis (distractor)
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| Mars-Aris
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"whereami" wrote:
Cyclo?
nice answer :wink: i hope you meant cyclosporine 
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