mjl1717
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What happens with the GFR, FF, peritubular cappilary pressure and F.F. if you constrict the efferent arteriole?? {Since no one gives a cold concise sharp, final answer } [except adeelmd] :evil:
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| huzefa
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I'll take a shot at it,
If you constrict efferent arterioles,
GFR will INCREASE (obviously)
PERITUBULAR CAPILLARY PRESSURE will DECREASE (So more reabsorption is possible)
GLOMERULAR CAPILLARY PRESSURE WILL INCREASE (Therefore more filtration will occur)
FILTRATION FRACTION WILL INCREASE Since GFR is larger (FF=GFR/RPF)
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| mjl1717
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Your on th right track, I know I didnt say it nor did you volunteer it, but what about renal plasma flow??
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| huzefa
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Renal plasma flow will decrease.
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| mjl1717
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Glad someone could get it right!
One more q what happens to all these parameters if you constrict the "afferent" arteriole:
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| huzefa
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Constrictiotion of afferent arterioles:
GFR decreases
RPF decreases
FF decreases
Glomerular capillary pressure decrease
Decreases across the board.
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| mjl1717
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Thx for the definitive answers!!! :shock:
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| sanz
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FF would be constant
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| mjl1717
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Sanz Ill agree with that mathematically since GFR and RPF both go in the same direction.
Thx
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| huzefa
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Actually Sanz is right. FF would be constant; this is probably because GFR AND RPF would BOTH decrease, thus leaving the ratio (GFR/RPF) constant.
FF can decrease if you have a ureteral stone (or blockage), or if you have increased plasma protein conc.
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| adeelmd
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I would think that ff would INCREASE cuz it is more affected by the decrease in RPF than the decrease in GFR... but i believe it is too specific for step one... In pg 306 of physio notes in kaplan... it specifically states that ff is related to RPF mainly, but in the chart halfway down the page it doesn't give an arrow (or a dash)... Anyways, i would say that it increases, and if that wasn't an option, i would pick constant.
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