mjl1717
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Why is Cilastatin administered with Imipenem??
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| Alina T
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cilastatin impedes the transformation of imipenem into a nephrotoxic compund in the renal tubules.
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| mjl1717
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It actually inhibits dihydropeptidase in the renal tubules so imipenenen is not inactivated!
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| Alina T
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Right! that's what i meant, but i couldn't remember the name of that enzyme... Thank you!
in conclusion, it has 2 effects:
1. keeps Imipenem active, so that it can be efficient in UTIs
2. protects kidney from being damaged by the toxic inactivated form of Imipenem
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