mjl1717
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What is the MOA of nucleoside reverse transcriptase inhibitors and name 5??
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| Alina T
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they interfere with DNA synthesis by reverse transcriptase (they cause chain termination due to slightly different structure than that of real nucleosides)
1.zidovudine
2.dideoxycytidine
3.dideoxyinosine
4.lamivudine
5.stavudine
and 2 extra ones:
6.abacavir and
7.tenofovir
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| MLF
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I think we should add some major Side effects of some. I'll start, zidovudine causes megaloblastin anemia, and ddI can cause pancreatitis.
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| mjl1717
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Great Alina!!- For this particular category the nomenclature is different ususally because of 3 letters.
The 1st Zidovudine-AZT
as said didanosine-DDI
Zalcitabine------DDC
Stavudine------ D4T
Lamivudine-----3TC
I dont have the last 2/
also peripheral neuropathy is a common significant side effect ..
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