Mars-Aris
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mechanism of action / side effects / clinical use
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| mdwannabe
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Phosphodiasterase5 inhibitor (increased levels of cGMP) prolonged vessel dilation. Bunch of SE's headache, red eyes, priapism, etc.
Used in Impotence.
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| Mars-Aris
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Topics: 70
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tadalafil does not have the same target as sildenefil (only similar mechanism )
tadalafil inihibts phosphodiesterase that degrades cAMP --> so it leads to increased cAMP inside the cell.
it has also longer duration of action than sildanefil (i think 36 hrs)
any other opinions ? 
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| doctorpieleanu
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3 years ago when I was in the 3th year I encountered a 45 year old woman who was taking Viagra. When doctor said what drug she was taking, we couldn't belive that. Viagra(sildenafil) was administred for pulmonary hypertension.We didn't ask if our patient was in a trial or sildenafil was routinely prescribed in patients with pulmonary hypertension.
I haven't heard about this new drug from the class of sildenafil.
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| doctorpieleanu
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here http://www.pulmonaryreviews.com/nov03/pr_nov03_si... U can find more about sildenafil as a treatment option for pulmonary hypertension
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| doctorpieleanu
Forum Newbie
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and here another articles on this topichttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Link&db=PubMed&dbFrom=PubMed&from_uid=15464333
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| Mars-Aris
Forum Elite
Topics: 70
Posts: 257
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trade name of tadalafil is "cialis"
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