mdwannabe
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Hyper Aldo-->Hypo K-->H for K exchange-->Alkalosis-->Hypo Ca-->Tetany
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| edgardny
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Also hyperaldosternism increase Na+ this drives Ca+ absortion by cotransport in kidney. Also higher uptake of Ca++ in the small intestine by the same mechanism. Causing in this way a hypercalcemic state.
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| MLF
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but tetany is caused by a HYPOcalcemic state??
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| edgardny
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I admit I am wrong dismiss my reply. I got consfuse with the mechanisms that implies this question. Chvostek's sign made me remember. A state of severe alkalosis cause tetany by the mechanisms mdwannabe explained.
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| Kazem
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very well replied mdwannabe! thankx to others too
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| mdwannabe
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thank you.
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| kalibonite
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Aldosterone at the distal tubule and collecting ducts causes Na+ retention and K+ secretion. During action potential formation in a neurone, Na+ is responsible for the depolarization phase and K+'s movement out is responsible for the repolarization phase. For a nerve that innervates a muscle, the repolarization phase of the action potential is responsible for relaxation. Due to depletion of K+, repolarization phase does not occur and hence muscle remains in a state of persistent contractility(tetany) due to firing of the Action potentials which don't die down by repolarization.
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