tuesday
Forum Senior
Topics: 7
Posts: 207
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Which among the causes of hemolysis would you do a Coomb's test?
A. Sickle Cell Dse.
B. AIH
C.Sickle cell trait
D.PNH
E.Hereditary Sperocytosis
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| lucky
Forum Guru
Topics: 23
Posts: 505
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AIH
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| drvic
Forum Elite
Topics: 10
Posts: 181
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you have to understand the basis of the Coombs' test- this is what they are testing here. Direct Coombs' test detects RBCs coated with neutralizing antibodies(that is why u do it in neonates with suspected ABO/Rh incompatibility). Indirect Coomb's Test detects circulating antibodies by adding Sheep RBCs etc. etc. - that is the overall principle here. now just run through the choices here.
Sickle cell disease - its hb defect. no role of any antibody/antigen here
AIH - Antibodies against RBC antigens - that's the One! but wait... let's look at the remaining choices too
Sickle Cell trait - same as above
PNH - defect in glycoprotein anchor of CD55(DAF) and CD59 (MIRL). undue complement activation on RBC surface causes hemolysis. so again no role of this test here.
Hereditary Sperocytosis - membrane structural defect in Spectrin protein. again no role of ag/ab coz RBCs are destroyed by spleen due to their reduced deformability in the narrow splenic sinusoids.
hope this clears everything once and for all.
regards
Drvic
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say what you mean... and mean what you say...
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| tuesday
Forum Senior
Topics: 7
Posts: 207
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ur both right. Nice explanation drvic. I think you mastered step 1 thru kaplan.
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