sing
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infectious mononucleosis is EB virus infection of B cells but the cells predominate in a blood film will be reactive T cell, CD8+. why? all the B cells are killed?
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| mdwannabe
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because CD-8 T-cells are reacting in the viral infection. Hence, though B-cells are infected, they are APC-professional, so they can present the viron in context of MHC-I and stimulate immune system. Hence T-Cell predominate in response.
Here is a question for a scholar... :-)
If CD-8 respond and kill off the infected b-cells... why people are infected with EBV for life?
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| MLF
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I thought all Antigen presenting cells present throught MHC II??
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| mdwannabe
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all cells in body are APC...but only several types are professional APC that can choose, MHC I or II.
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"Life not lived for others, is not worth living" Uncle Einstein
"A life is not important, except in the impact it has on other lives" -Jackie Robinson
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| MLF
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Thanx
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| sing
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right. thanks for the cd8 explanation.
but for the APC and professional APC part, i need do more study. never heard of prefessional APC. and for APC, as i remember, they include b cell, macrophage and dendritic cells instead of all the cells in the body as you mentioned. :?:
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