mjl1717
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What is the difference between Type II and Type III Hypersensitivity Rxns give examples of each?
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| youknowho7
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I think for remembering all the type of hypersenstitivity reactions just remember ACID
Type 1 Anaphylactic
Type II Cell Mediated
Type III Immune Complex
Type IV Delayed Hypersensitivity
and the examples of type II and III are Mismatched transfusin reaction and certain Immune Complex mediated Glomerulonephritis
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| youknowho7
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I am sorry C ( in ACID) is for is for Cytotoxic not cell mediated, cell mediated is type IV , sorry abt that
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| hamed
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this is a good one and i cost me a day to do research on it. first aid for step one is also a good source.
type II is the cytotoxic one, meaning that the atibodies from a host will attach the foriegn cells in case of blood transfusion with wrong(ABO)type or the host's own body cells in the case of goodpasture syndrome which could lead to kidney failure. therefore, the antibody is already present in the host body--> my undrestanding.
type II is different from from type IV in which you have the T lymphocyte present --> graft rejection.
type III is atibodies of the host against the atigen molecules. example in SLE. these will form complexes antigen+antibodies and they will deposite in body tissues. focal segmental glumerolonephritis. or another example is serum sickness which is caused by administration of some drugs. the deposition of this complexes will cause damage to the organs of the host's body.
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| mjl1717
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Can anyone add to this q on the difference Only between Type II and Type III Hypersensitivity Rxns with examples?
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| Yulia
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Type 2 is mediated by antibodies against tissue antigens. It can either lead to the tissue destruction - Hemolytic disease of newborn, transfusion reaction, goodpasture sd, rheumatic fever, hyperacute graft rejection etc. Another result is alteration of cellular structure and/or function as in Miasthenia Gravis and Graves disease
type 3 is caused by high levels of circulating soluble immune complexes, which results in systemic rather than organ specific damage. Examples: SLE, RA, PAN, Poststreptococcal GN, serum sickness.
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