Mars-Aris
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name 2 diseases associated with missense mutations
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| MLF
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Cystic Fibrosis = Some people would argue its frameshift, but according to path robbins, its missense.
Sickle cell anemia
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| Malaysian
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I think cystic fibrosis is an in-frameshift mutation??But I've seen those discussion where the closest possible answer to a similar situation was missense.
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| Mars-Aris
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two examples of missense mutation:
1.sickle cell
2.marfan's
cystic fibrosis is surely not frameshift / or missense
in CF there is a deletion of 3 bases -so 1 aminoacid = phenylalanine- is completely lost
in missense mutation you have a change in the codon --> different aminoacid
so again you can not say that CF is a missense mutation
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| Malaysian
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its not frame shift I agree as for this to happen you can't have deletions of multiple of 3 but when you do have a deletion involving multiples of 3 its called as in-frame mutation.
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