mjl1717
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What good is Hydroxurea in Sickle Cell disease??
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| Mars-Aris
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i think it reduces the frequency of the painful vasooclusive crises
is there any mechanism ?? a possible guess would be an increase in HbF in RBC... :idea:
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| mdwannabe
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Well it really does have a role in the induction of the HbF gene. So the apparently that is the machanism for reduction.
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| Kazem
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Sickle cell disease (SCD) has many complications namely vaso oclusive pain crisis, Acute Chest syndrome, stroke, leg ulcers, aseptic necrosis on bone and priapism. hydroxyurea is given to SCD patients to make their bone marrow produce more fetal Hb. this of course causes other changes in the marrow productions leading to neutropenia and thrombocytopenia.
the other reason hydroxyurea is administered is b/c it helps to prevent the Acute chest syndrome. with regard to leg ulcers, aseptic necrosis of bone, and priapism the effect of hydroxyureaon these conditions is unknown.
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| Kazem
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Hydroxyurea Mechanism of action/Effect:
Hydroxyurea is classified as an antimetabolite. Hydroxyurea is thought to be cell cycle–specific for the S phase of cell division.
The specific action of HU is on ribonucleotide reductase. Ribonucleotides are reduced by ribonucleotide reductase to deoxyribonucleotides; this reduction reaction is impeded by HU, which limits DNA biosynthesis. Consequently HU is an S-phase-specific cytotoxic and antineoplastic agent that interrupts the cell cycle at the G1 and S phases
Pharmacologic effects of hydroxyurea that may contribute to its beneficial effects in sickle cell anemia include increasing hemoglobin F levels in red blood cells (RBCs), decreasing neutrophils, increasing the water content of RBCs, increasing deformability of sickled cells, and altering the adhesion of RBCs to the endothelium
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| mjl1717
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Guys Good- I was looking for 2 things:
Mdwannabe said it in the fewest amount of words:
1)Increases HbF
2)inhibits ribonucleotide reductase
3)Thx for the extras
Also kazem-neutopenia is beneficial in sickle cell anemia???
:shock:
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| mjl1717
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delete
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| Kazem
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mjl1717, sorry for the long answer. of course neutropenia is not beneficial in SCD and I think that's why such patients are also on antibiotics.
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