mjl1717
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What is the mech. of action of the alpha 1 receptor?
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| EMI777LY
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Eye radial m---contraction--mydriasis, no cyclopedia No effect on lens at all
-Arterioles-- constrict ^PVR :arrow: ^diatolic pressure :arrow: ^afterload
Veins :arrow: constrict-- :arrow: ^venous return
:arrow: ^preload
Male sex organs Works on vas deference :arrow: ^ajaculation
Bladder:arrow: constrict :arrow: urinary retention
Kidney decrese renin release (because vasoconstriction :arrow: decrease renin)
Liver- increse glycogenolysis
it works on Gq coupled mechanizm: IncreaseDAG :arrow: protein kinaseC .IP3 :arrow: Increase intracellular Ca
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