mjl1717
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Name 5 hormones that can act on the kidney.
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| MLF
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I have three
ADH, Aldosterone, PTH
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| vrach
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Atrial Natiuretic Factor, 1,25-Dihydroxycholecalciferol
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| mjl1717
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I dont know about 1,25 but AngiotensinII should be included.
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| mdwannabe
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1,25 does not act on it...rather kidney acts on that, and it is not a hormone. So ADH, Aldo, Angio, ANP, PTH. I can't think of anything else.
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| mjl1717
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Thx mdwannabe--yesterday I noticed [4A's and 1 P]
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| mdwannabe
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:-)
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| Malaysian
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doesn't vit. d have any affect in absorption of calcium and phosphate from kidney?
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| VM
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they are looking for 5 HORMONES.. so .
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| vrach
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I just came across this today in Ganong Physiology, 21st edition:
"1,25-Dihydroxy-cholecalciferol is a steroid hormone formed from vitamin D by successive hydroxylations in the liver and kidneys. Its primary action is to increase calcium absorption from the intestine."
So it seems that 1,25-Dihydroxy-cholecalciferol is a hormone.
Besides its primary action is in the intestine, it also facilitates reabsorbtion of Ca in the kidneys.
So should this be considered as a hormone which can act on the kidney?
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| mdwannabe
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Took me a bit of thinking and some more reading.
So here is the verdict:
1,25-dihydroxycholecalciferol is a steroid hormone, its mechanism of action involves stimulation of gene transcription and synthesis of new proteins, which have the following physiologic actions.
1,25- dihydroxycholecalciferol induces the synthesis of a vitamin D-dependent Ca-binding protein called calbindin D-28K, a cytosolic protein that can bind four Ca ions.
Ca diffuses from the gut lumen into the enterocyte cell down its electrochemical gradient.
Bound inside the cell to calbindin D-28K, and subsequently is pumped across the basolateral membrane into blood by a Ca-ATPase.
The exact role of calbindin D-28K in promoting absorption in intestinal epithelial cells is uncertain.
It may act as a shuttle, moving Ca across the cell from lumen to blood.
Or it may act as a Ca buffer to keep intracellular free Ca low, thus maintaining the concentration gradient for Ca diffusion acroacross the luminal membrane.
The actions of 1,25-dihydroxycholecalciferol on the kidney are parallel to its actions on the intestine — it stimulates both Ca and phosphate reabsorption.
I found this very intersting...I love going deeper..., makes info stick for long time.
Thank you Vrach for the stimulus.
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