olena_r
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What is the mechanism of O2 dissociation curve shift to the right with the increase of 2,3 bisphosphate and what's the most common cause of 2,3 bisphosphate increased levels?
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| olena_r
Forum Junior
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*i meant 2,3 BPG - bisphosphoglycerate. Sorry, typo
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| adeelmd
Forum Elite
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2,3 dpg causes a decrease in the affnity of O2 for hb, so it needs a higher PO2 to obtain the same % saturation. I would guess the most common cause would be high altitude... but not sure.
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| Kazem
Forum Elite
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hypoxia I guess is the main cause which stimulates increased production of 2,3bpg. 2,3bpg in turn as adeelmd said causes a decrease in the affnity of O2 for hb leading to more release of o2 in tissue therby compesating for the shortage of oxygen. high altitude of course always reminds me of a trigger for the production of erythropoietin from the enothelial cells of the peritubular cappilaries in the kidney again due to hypoxia. 
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| skylark
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the deoxy form has a higher affinity for 2,3 BPG. by bounding to the T form it stabilizes it and so the oxygen is released to the tissues.
2,3 BPG is increased in hypoxia and anemia to facilitate the O2 distribution to the tissues
HbF only bind 2, 3 BPG weakly so that it has a higher O2 affinity
normally there is a raport of 1:1 between Hb and 2.3 BPG. its increased by low O2 and anemia and decreased in tranfused blood (hence the need for inosine in the storage medium)
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| moonjogger
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I haven't been able to read up what the stimulus for 2,3BPG synthesis is. Is it hypoxia? Also, by synthesising 2,3BPG you are bypassing phosphoglycerate kinase which means you are synthesising 2 less ATP per glucose. Considering that the anaerobic glycolytic pathway in RBCs produces net 2 ATP per glucose, that's all the ATP lost. The effect of 2,3BPG had better be worth the loss of ATP.
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| olena_r
Forum Junior
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thank you guys . That was helpful
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