Gario
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Q1. Besides EBV, is there any pathogen causing IM?
(CMV causes IM-like syndrome.)
Q2. How can we distinguish whether a patient contracts IM or VAHS (virus-associated hemophagocytic syndrome)?
Any help would be greatly appreciated!
Thank you beforehand.
Gary
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| bactitech
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A Monospot (or similar) test is the fastest way to detect mononucleosis. Performed in laboratories on a STAT basis daily all over the US! :-) Our current method takes 5 minutes and only needs a couple of drops of serum.
I'm curious about VAHS - I've never heard of that in 30 years in the lab biz. New terminology for old syndrome or something new that I haven't heard about? Just curious...
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Clinical Microbiology since 1974
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| mdwannabe
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if I am not mistaken that is the syndrome also called "Angry Macrophage Syndrome" .. Macs get fulled by some virus and start feeding on RBC's ... then get in to BM and have big dinner...dining on Megacarries and RBC precursors. People present a couple of weeks post viral illness, with anemia and thrombocytopenia. Its been reposrted first in Japan , I think.
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| Gario
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Definition (Risdall, et al in 1979, 19 cases)
(Cancer. 1979 Sep;44(3):993-1002.)
1. Benign generalized histiocytic proliferation
2. Marked hemophagocytosis
3. Systemic virus infection: EBV, CMV, HSV & Adenovirus
4. Fever, generalized constitutional symptoms and myalgia & malaise
5. Hepatosplenomegaly with generalized lymphadenopathy
6. Abnormal LFT with more severe coagulopathy
7. Pancytopenia and appear very toxic
8. Most in immunosuppressed pt: allograft recipient, leukemics, steroid Rx
9. 80% fatal infectious mononucleosis (IM) with VAHS
10.High mortality in VAHS: Use of immunosuppressive agents increased mortality
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| bactitech
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http://www.bloodline.net/stories/storyReader$1901
Found this on bloodline.net. I have a friend who is a hematology supervisor at a BIG hospital. I am mailing her this thread and hopefully she'll give me the scoop.
Thanks for updating my hematological knowledge.
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Clinical Microbiology since 1974
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| bactitech
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I heard from her - she and her pathologist didn't think they had ever seen this, so it must be pretty rare (and they're in a BIG city).
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| Gario
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Thank you very much!
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