mjl1717
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Can anyone make a couple of profound statements about urea?
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| rubensssss
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End product of Aminoacids metabolism.
Produce in urea cycle(in Liver)
Filter by Kidney.
Reabsorb by proximal tubules.
GFR if reduces allows to reabsorbed Urea.
GFR if increase allows reduces reabsortion,more urea is found in urine.
Measure in Lab. as BUN (7-18 mg/dl).
Azotemia increase serum BUN.
Prerenal azotemia:
Reduce GFR with normal renal function,Ex CHF and Hypovolemia
Renal azotemia:
intrincic renal disease.ExAcute tubular necrosis.
Postrenal azotemia:
Secundary to Urinary tract Obstruction.Ex Obstruction of the urethra in prostatic hyperplasia.
This is some, probable you already know this.
.
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| mjl1717
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Sorry -Idid not mean random facts about urea.
The q should have been stated:
Can anyone mention any profound facts about urea in direct reference to renal physiology?
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| Kazem
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* ability of urea to concentrate the urine by adding to hyperosmolarity of the renal medulla by 40% (500 mOsm/L)
* 40-50% of filtered load of urea is excreted.
* urea is passively reabsorbed in the proximal tuble, thin descending limb and slighty in the thin ascending limb of loop of Henle.
* Urea is avidly reabsorbed by diffsion from the inner medullary collecting ducts when there is water deficit and blood conc. of ADH is high.
* Urea reabsorbed from the inner medullary collecting ducts can leak back to the loop of hele to increase hyperosmolarity in the meulla.
* malnutrition, is associated with a low urea conc. in medullary interstisium and considerable impairment of urine concentrating ability.
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| mjl1717
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Thx Kazem-thats what i was looking for.
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