mjl1717
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Which are the irreversible enzymes in glycolysis?
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| mani
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glucokinase/hexokinase
PFK
pyruvate kinase
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| amitjosh
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This is important coz gluconeogenesis is the exact reversal of glycolysis but since these three enzymes are irreversible.
In gluconeogenesis:
Pyruvate kinase is replaced by pyruvate carboxylase and Phophoenolpyruvate carboxykinase.
PFK-1 is replaced by Fructose 1-6 Bisphosphatase.
Glucokinase is replaced by the enzyme Glucose - 6 phosphatase
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