Erythropoietin site

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Erythropoietin site

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Renegade
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Topics: 18
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10/21/04 - 09:09 PM

I am terribly sorry, but is there any particular reason for me to be so puzzled about this question...?

-«Where exactly is erythropoietin made?»

From my book (Stevens - Lowe -english authors) I learned the exact location was unknown, but imunochemistry suggested it was at the renal cortex interstice.

Now Goljan calmly claims the «endothelial cells of the peritubular capillaries» are responsible...

I'd very much like to believe him (as always), but a little research showed that some disagree. Consider this source and, well, does concern murine kidney. Maybe human erythropoietin comes from a different place? And yet this site suports Goljan's statement... Any ideas?

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mdwannabe
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10/22/04 - 06:15 AM

As far as it known ...EPO cones from renal cells, peritubular seems to be correct. Because of low O2 tension around there, so little change in 02 concentration will produce release of EPO.

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mdwannabe
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10/22/04 - 06:18 AM

to add...ofcorse there is some EPO made in liver, since liver makes everything, and there is always several sites of production for each element in the body, in case the primary site is in trouble and needs some bailing out.

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"Life not lived for others, is not worth living" Uncle Einstein
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Ahab
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10/22/04 - 03:33 PM

always thought it was the macula densa cells myself

Renegade
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10/22/04 - 05:59 PM

Macula densa? Those are quite involved in renin production... but erythropoietin? Such an important hormone should be produced nearer to a blood vessel...

Anyway, I once heard it was thought mesangial cells were involved. That's the problem, isn't there a safe source to know? A question like this concerns kidneys, blood, homones... it's likely they make a question around it. Hence my concern.

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«The desire to take medicine is perhaps the greatest feature which distinguishes man from animals.» W. Osler

Ritalin
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Topics: 3
Posts: 30

12/14/04 - 11:13 AM

"Renegade" wrote:
Macula densa? Those are quite involved in renin production... but erythropoietin?

Neither they are. The juxtaglomerular cells are the ones that produce renin. Those are modified smooth muscle cells found, of course, in the media of the afferent arteriole.

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