luckiest
Forum Senior
Topics: 12
Posts: 82
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A 15 years old boy,come to hospital with low back pain for 3 years.
He complaint pain on both hips and norturnal stiffness improve with exercise.
What is the pathogenesis hypothesis in this patient's disease?
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| mdwannabe
Forum Guru
Topics: 37
Posts: 1,133
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Path hypothesis includes molecular mimcry due to some viral infection in patients with HLA-B-27. AB formed against joint space material with release of cytokines, inflamation, repair and fibrosis. Eventually leading to fusion of involved bones.
Bamboo spine is the sign of advanced disease.
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"Life not lived for others, is not worth living" Uncle Einstein
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| luckiest
Forum Senior
Topics: 12
Posts: 82
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 COrrect! the patient has ankylosing spondylitis
By the way when you say "joint space" do u include the pathlogy usually occur at "enthesis" the end when joint ligament
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| luckiest
Forum Senior
Topics: 12
Posts: 82
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As my post above I didn't mean to bluff !
But I really don't know that does enthesis relevent joint space
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| mdwannabe
Forum Guru
Topics: 37
Posts: 1,133
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Yes, enthesitis with chronic inflammation.
Cells involved include CD4+ and CD8+ T lymphocytes and macrophages. Cytokines, involved include TNF-alpha and TGF-beta, leading to fibrosis and ossification at sites of enthesitis.
___________________
"Life not lived for others, is not worth living" Uncle Einstein
"A life is not important, except in the impact it has on other lives" -Jackie Robinson
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