vallmo
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What effect does a carbon anhydrate inhibitor have on urinary HCO3-excretion, and by what mechanism? What type of acid base disorder could result from such a drug?
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| vrach
Forum Junior
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A carbonic anhydrase inhibitor would:
inhibit the indirect reabsorbtion of HCO3 in the renal proximal tubule, leading to a loss of HCO3 in urine->metabolic acidosis.
It would also inhibit the secretion of Hydrogen ions in the distal tubule and collecting ducts->metabolic acidosis
Net result=> metabolic acidosis, alkaline urine=> respiratory compensation via hyperventilation, hypokalemia.
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| mjl1717
Forum Hero
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Well its nice when it all comes together> So this is why it makes sense for an M.D. to give a carbonic anhydrase inhibitor to a pt who say hes going to visit someone on the top of a high mountain (where hes prone to resp. alkalosis.)
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| mani
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it would "enhance" renal compensation of resp alkalosis
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| vallmo
Forum Junior
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good reply Vrach!
Just want to write down the explanation from the book:
"Carbon anhydrase plays a critical role in the reabs of HCO3- by the cells of the proximal tubule and by intercalated cells of the collecting duct. Inhibition of this enzyme would therefore inhibit the reabs of HCO3- at these sites.
Because of the large fracton of the filtered load of HCO3- reabsorbed by the proximal tubuli, the effect at this site is quantitatively more important. With decreased reabs, more HCO3- would be excreted in the urine, and urine pH would be alkaline.
This loss of HCO3- results in metabolic alkalos"
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| luckiest
Forum Senior
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This loss of HCO3- results in metabolic alkalos"
is it metabolic acidosis.
Net result=> metabolic acidosis, alkaline urine=> respiratory compensation via hyperventilation, hypokalemia
Is met. acidosis if last long more than 12 hrs. will result in hyperkalemia ?
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