mjl1717
Forum Hero
Topics: 956
Posts: 5,452
|
Can someone describe in detail the 1st half of the urea cycle?
___________________
Smell the coffee! "Is That an Osler move??"
|
| mani
Forum Guru
Topics: 104
Posts: 1,403
|
perhaps not in detail but a bit in short...
assuming that first half refers to the part occuring in mitochondria...
ammonium ion and bicarb in the presence of 2 ATPs combine to for carbamoyl PO4, catalyzed by carbamoyl PHO4 synthetase I. Then ornithine transcarbamoylase adds ornithine to carbamoyl PO4 to form citrulline that leave mitochondria t enter cytoplasm
___________________
Sincerity and hard work are the keys to success!
|
| mjl1717
Forum Hero
Topics: 956
Posts: 5,452
|
Good -Didnt want to take us thru the entire cycle because of TIME!!
___________________
Smell the coffee! "Is That an Osler move??"
|
| mani
Forum Guru
Topics: 104
Posts: 1,403
|
not bcoz of TIME, rather bcoz question was asking for 1st part only
ok here is the rest of it:
in the cytoplasm, Asp is added to citrulline yielding argininosuccinate catalyzed by argininosuccinate synthetase. during this reaction ATP is broken down into AMP & PPi..
Nxt, argininosuccinate lyase breaks down the argininosuccinate releasing fumarate and producing Arginine that is broken down by arginase to yield urea and ornithine (which goes to mitochondria to be used again)
___________________
Sincerity and hard work are the keys to success!
|
|
| |
| | | | |
