q on urea cylce

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q on urea cylce

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3 Posts

Malu
Forum Junior

Topics: 8
Posts: 44

10/06/04 - 01:56 PM

why are there elevated levels of uracil and orotic acid in the urine when u have a ornithine transcarbamoylase deficiency :?:

mani
Forum Guru
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Topics: 104
Posts: 1,403

10/06/04 - 04:31 PM

this deficiency leads to accumulation of carbamoyl PO4 which is also a substrate for aspartate transcarbamoylase in pyrimidine synthesis. so divergence of carbamoyl PO4 to pyrimidine pathway leads to excess of ortic acid and uracil

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Malu
Forum Junior

Topics: 8
Posts: 44

10/07/04 - 03:08 AM

aaah :idea: got it, thanks

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