mani
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whats organisms (/diseases) are associated with superantigens?
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| kpm24
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grp A beta hemolytic strep (scarlet fever, cellulitis)
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| mani
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what else??
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| niti
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Hey mani,
Molecules produced during infectious process and known as superantigens include
staphylococcal enterotoxins
toxic-shock syndrome toxin-1 and
streptococcal pyrogenic exotoxins.
They are responsible for systemic toxicity because of overproduction of proinflammatory cytokines .
niti
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| mani
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come on buddies, there are a few more. list them here
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| niti
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Hi mani,
I couldn't find more...so,please help me out here and post more details about this topic ..
niti
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| santaclara
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Exfoliative Toxin A but that also include in staphy.
what else mani.
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| santaclara
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ALL superantigens mension above r Exogenous superantigens.
mani r u asking about Endogenous superantigens?
pls reply.
thanx
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| mani
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i dont think there is some endogenous superantigen. somewhere i read that other organisms also have superantigens besides staph and strep like
C perfrigens
Y eterocolitica
Mycoplama arthritiris
santaclara, can u tell me reference for exfoliatin as superantigen? according to MRS & jawetz its a protease that degrades dermogliadin
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| santaclara
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u r right mani. but i just read this on internet some where.
Superantigens are molecules that stimulate, independent of antigen, those T- cells displaying a particular beta chain variable region (Vbeta) of the T-cell receptor. These molecules are the most powerful T-cell mitogens known inducing biological effects at femtomolar concentrations. Recently it has been demonstrated that superantigens possess biological properties, e.g., lethality and emesis, which are separable from their T-cell mitogenicity. Studies have implicated superantigens in such diseases as food poisoning, toxic shock syndrome, scarlet and rheumatic fever, arthritis, multiple sclerosis, diabetes, sudden infant death syndrome, Kawasaki syndrome (a leading cause of acquired heart defects), and AIDS.
The best characterized superantigens are the microbial toxins from Staphylococcus aureus and Streptococcus pyogenes. The Ohlendorf lab has studied two staphylococcal superantigens - Toxic Shock Syndrome Toxin-1 (TSST-1) and Exfoliative Toxin A (ETA).
i also didn't read this in kaplan also.
any way any comment from u .most welcome buddy. lol
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| mani
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i got the info in my post above from a website as well but we just cant trust the websites, need to have some reference from book as well. thats the reason i posted this question.
i hope somebody can share any info about this if someone has
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| santaclara
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ok thanx.can u tell where didu read about these three pls.
C perfrigens
Y eterocolitica
Mycoplama arthritiris
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| mani
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sorry i dont remember the address
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| santaclara
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address? what do u mean by address lol
any way thanx for reply.
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| mani
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i was talking about website website address
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| kpm24
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"Pyrogenic exotoxins are non-specific activators of the immune system (super antigens)."
p. 332 Table V-3-5
Kapaln Home Study Kit General Principles
this is where I read about super antigens... there could really be a lot of them out there then.
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