Anno Domini
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I think that in people with diabetes in the cells of lens and retina and other which have aldose reductase and do not have sorbitol dehidrogenase , glucose is entering in them and changing into sorbitol.Sorbitol (it can,t exit the cell) is osmoticaly active and he pulls H2O in the cells and they swell.
In galactosemia with deficiencies of galatose 1 phosphate urydyltransferase or galactokinase , galactose is acumulating in the cells and turning to galacitol (with the help of aldose reductase) and it does the same thing in the retina as sorbitol.
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| Anno Domini
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Maybe because fructose is affecting mostly the liver metabolism
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| Yulia
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You're absolutely right about glucose and galactose reduction.
Fructose is a ketose sugar, and therefore is not a substrate for aldose reductase in the lens. That's why we see no cataracts in these patients
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| Anno Domini
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#-o Ketose sugar ! I didn't think about that.
That was an excelent question Yulia
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