amitjosh
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1) A 50-year-old man has felt vague abdominal discomfort for the past 4 months. On physical examination he has no lymphadenopathy, and no abdominal masses or organomegaly can be palpated. Bowel sounds are present. An abdominal CT scan shows a 20 cm retroperitoneal soft tissue mass obscuring the left psoas muscle. A stool specimen tested for occult blood is negative. Which of the following neoplasms is this man most likely to have?
A Melanoma
B Hamartoma
C Adenocarcinoma
D Lymphoma
E Liposarcoma
2) A 40-year-old woman has had a feeling of abdominal discomfort for the past 8 months. On pelvic examination, there is a right adnexal mass. An abdominal CT scan demonstrates a 7 cm cystic mass involving the right ovary with small areas of calcification. The uterus is normal in size. The right fallopian tube and ovary are removed surgically. Grossly, the mass on sectioning is filled with abundant hair and sebum. Microscopically, the mass has glandular spaces lined by columnar epithelium, squamous epithelium with hair follicles, cartilage, and dense connective tissue. Which of the following statements regarding this type of neoplasm is most appropriate?
A A sarcomatous element is usually present.
B A human papillomavirus infection preceded development of this mass.
C Metastases are unlikely to be present.
D Tissues resembling those from an embryo can usually be seen.
E Such a mass is often seen to arise in the testis.
3) A 56-year-old man has had a chronic cough for the past year. He is a non-smoker. He had an episode of hemoptysis 3 days ago. No abnormal findings are noted on physical examination. A chest x-ray demonstrates a 6 cm perihilar mass. A sputum sample is collected, and the sputum cytology report reads "Atypical cells present suggestive of squamous cell carcinoma." Which of the following environmental exposures is most likely to be associated with these findings?
A Asbestos
B Radon
C Silica
D Benzene
E Formaldehyde
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| tdr
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1-e
2-e
3-a
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| mjl1717
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1)c
2)e
3)a
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| Alina T
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1. E
2. E
3.B
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| santaclara
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1)C
2)E
3)A
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| meghana jadhav
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e
c
b
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megha
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| Malaysian
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My answer matches that of meghana
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| polkos
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1]e
2]d
3]a
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| amitjosh
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Meghana and Malaysian are right
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| amitjosh
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Regarding Q2 forgot to mention that the sentence
"Microscopically, the mass has glandular spaces lined by columnar epithelium, squamous epithelium with hair follicles, cartilage, and dense connective tissue. "
suggests that the neoplasm is cystic and circumscribed which is consistent with a mature cystic teratoma and hence benign.
Testicular teratomas are more likely to be malignant.
Regarding the next question I think asbestos is related to mesothelioma. It is also related to bronchogenic carcinoma but in smoker
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| dr_singh246
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can u clarify on radon. i think its asbestos
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| amitjosh
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Asbestos is related to mesothelioma not a squamous cell carcinoma in non smokers.
Radon by virtue of its radioactive properties is also a carcinogen, and is related to squamous cell carcinoma of the lung.
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| VM
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It might be helpful to know that Radon is the second leading cause of lung cancer in the united states causign as many as 15 to 22 K deaths/year.
Non smokers with no other obvious carcinogen like occupational exposure presents with lung cancer consider Radon...Ofcourse if they smoke the risk compounds
VM
Proud owner of In Home Radon Reduction System :lol:
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| adeelmd
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asbstos exposure is linked with bronchogenic cancer (on it's own). While Mesothelioma is exclusive to asbestos, the incidence of bronchogenic cancer is higher than mesothelioma following asbstos exposure. The reason for this is that people develop and die from lung cancer before the "incubation period" (around 30-40) years for mesothelioma. I don't know if radon is more common than asbestos (do you have a source vm)
Could someone explain liposarcoma? is it cuz of the location? i wuz completely clueless on that one.
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| VM
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Asbestos is not as much of an exposure problem of late since EPA has worked on banning most of asbestos related products in the US. Midwest is where radon is more prevalant... and where the Iowa Radon Lung cancer study has been done at the University of Iowa. I skimmed the report and also found the information at the NIH site..
http://cis.nci.nih.gov/fact/3_52.htm
I hope it clarifies ..
VM
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