mani
Forum Guru
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lets go this way:
at very beginning, aortic stenosis will cause decrease in MAP. this wil lead to compensatory overactivity of heart in short term via sympathetics, while in the long term there will be hypertrophy of left ventricle. these will lead to increase force generation whixch will lead to increased pressure in left ventricle and bringing the MAP towards normal. but as always, compensation is never complete
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| vrach
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The increased ventricular systolic pressure (read force inplace of pressure) is used to overcome the increased resistance to blood flow out of the ventricle (due to the stenotic aortic valves). So almost the entire excess pressure is lost before the blood enters the aorta.
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Thanks Mani and Vrach,
I think Vrach's explanation is more justified.
The stenotic aortic valve acts as a major rssistance in series with systemic circuit so
"The increased ventricular systolic pressure (force) is used to overcome the increased resistance to blood flow out of the ventricle. So almost the entire excess pressure is lost before the blood enters the aorta." and eventually the MAP is maintained in the normal range.
(ref Kaplan Physio page 194 and 81)
Thank you guys ,you have inspired me to read and think more. 
-Josh
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| mani
Forum Guru
Topics: 104
Posts: 1,403
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josh, if u read my post again, i meant the same thing but i have gone into short and long term pathophysio of the process involved. isnt it?
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Dear mani,
Thanks for asking me to read again.
I was only concenred for the Physiological aspect of AS and MAP but looks noe that you have explained the pathology of process well and in short.
Thanks again.
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