mani
Forum Guru
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in primary hyperaldosteronism GFR is not decreased, so there is no increase in proximal tubular reabsorption of Na. but in sec hyperaldosteronism, the cause is actually reduced effective intavascular volume, leading to reduced GFR and hence increased proximal tubular Na absorption. increased Na absorption leads to volume over load.--->edema. causes of sec hperaldo are like CCF, cirrhosis etc etc
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