Anno Domini
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Which are the main regulatory enzymes of glycolysis?
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| mksl
Forum Newbie
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hexokinase, phosphofructokinase, pyruvate kinase
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| neva
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Here is one of them:
9 mo old baby is evaluated for hemolytic anemia. The oxygen dissociation curve is shifted to the right. Which enzyme deficiency is most likely related for this Pt's condition?
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| Anno Domini
Moderator
Topics: 293
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Well I would say pyruvate kinase or hekoxinase , but i am not sure why would that decrease o2 affinity.Can you please explain me that.
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| neva
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Absolutely, Pyruvate kinase deficiency. In this case right shift is caused by accumulation of 2,3-BPG due to abnormal anaerobic glycolysis. Actual intermediate is 1,2-BPG but RBCs have phosphoglycerate mutase, wich produces 2,3-BPG, which binds to Hb A and decreases its affinity for oxygen. Plus, decrease in ATP production will result in decreased Na/K -ATPase activity, and therefore loss of ion balance causes in osmotic fragility, leading to swelling and lysis. RBCs destroyed in a spleen.
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| Anno Domini
Moderator
Topics: 293
Posts: 727
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I understand .Thanks.
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| neva
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Anytime 
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