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 sensitivity/specificity trade off  

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you may have seen the usmle biostats question that involves a graph with two histograms and a line (cut-off value) down the middle. the question then asks what happens to the sensitivity of the test if you shift the line to the left...

well, if the answer isn't really clear to you, i explained it with the help of animations in this video....

in addition to discussing what happens to the specificity and sensitivity when the threshold for a positive test changes, i discussed the significance of the overlap between the group of patients with the disease and without it.

if you have any comments, please feel free to make them.... criticisms are appreciated.

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