nlamichhane
Forum Newbie
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I am confused why ECF volume contraction increases HCO3 reabsorption, pls some clarify.
thanks
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| Alina T
Forum Elite
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there are 2 mechanisms I can think about:
1. low ECF -> low EABV (effective art blood flow) -> increase Na reabsorbtion in PCT in exchange with H+ -> H+ in tubule results in "reclamation" of HCO3- (one of the 2 mechanisms of HCO3 reabsorbtion in kidney, the other one is regeneration)
2. low ECF -> low EABV-> increase in renin synth -> increase angiotensin II, which stimulates again HCO3 reabsorbtion in PCT.
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| dxtxpx
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http://zzorglub.ifrance.com/zzorglub/cmu/acidobas...
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| bluedusk
Forum Elite
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alina, i don't think there's much to add. one q - what's your understanding of the mechanism of increased Na resorption proximally based on low EABV?
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| Alina T
Forum Elite
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it's all based on Starling forces. low EABV causes an increase in oncotic pressure and decrease in hydrostatic pressure in peritubular capillaries, these changes increasing the Na+ and water reabsorbtion in PCT. this accounts for about 2/3 of the entire Na+ reabsorbtion in the kidney.
Good site again dxtxpx!! thanx!
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| nlamichhane
Forum Newbie
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Thank you guys, nice link and explanation you gave
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