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 Hypercoagulation in nephrosis?  

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Why do a patient with minimal change nephrosis develop hypercoagulability? Wont they rather leak coagulation factors?


This is an interesting topic! There are several alterations. Urinary losses of antithrombin 3, protein c and s as well as some coagulation factors are prominent in nephrosis. Levels of fibrinogen and t-pa are increased. And these changes lead to hypercoagulabilty, both arterial and venous.

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