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 Nephron plasma flow  




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Author2 Posts
  #1

Hello all,

I am very confused over one aspect of renal physiology - information in table does not make sense to me. At least not today.

If we constrict efferent arteriole and therefore our GFR goes up (because the pressure goes up) - how it is possible that nephron plasma flow goes down?
Is nephron plasma flow referred to plasma filtrate in nephron?

Many thanks smiling face




  #2

Think of the efferent arteriole as any arteriole in the body- when it constricts less blood goes through, hence decreased blood flow. This constriction also increases hydrostatic pressure before that point and thus increases filtration (starling forces).
Applied to your question: the constricted arteriole increased hydrostatic pressure in the glomerulus which lead to increased filtration. However, increased resistance caused by that constriction lead to decreased flow. As per Q= P/R. ( the essence really is that the constriction caused decreased volume of blood flow, but increased the fraction of that volume that is filtrated)





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