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 Drug Excipients  

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does anyone have any hints on possible excipients that we could use in drug formulation for a drug with a weight of around 850 Da and being a class III or IV molecule aimed to target the liver?
So far we┬┤ve tried PEG400, 5% Tween 80 and at 5 hours after oral gavage our drug concentration in the liver peaked. We measured the concentration and calculated that around 0.002 % of it was going to the liver and we would love to have something around 5% if thats realistic wink

Thanks for any of your suggestions wink

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