Loss of Heterozygosity

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Loss of Heterozygosity

Author

5 Posts

timtim
Forum Junior

Topics: 14
Posts: 64

09/13/04 - 08:42 AM

Can anyone let me know what is loss of heterozygosity?

Thanks

nyimg
Forum Newbie

Topics: 9
Posts: 30

09/13/04 - 02:59 PM

Is it related to the autosomal dominant disease...say the "good" gene mutation occurs so that the dominant disease can be expressed? It is also called "two-hit model". Please correct me if I am wrong.

Malaysian
Forum Guru

Topics: 28
Posts: 778

09/15/04 - 07:29 AM

I didnt undertasand can you pls be more elaborative nyimg

nyimg
Forum Newbie

Topics: 9
Posts: 30

09/17/04 - 02:17 PM

Taking a tumor suppressor mutation as an example, generally the child gets one mutated tumor suppressor gene from one of his/her parents (heterozygous). Given that the other, healthy, copy can produce protein to prevent tumor formation, this child is fine. However, this healthy gene some times also gets mutated (loss of heterozygosity), no gene that can be expressed to prevent tumor...the child starts to develop tumor cells.

Malaysian
Forum Guru

Topics: 28
Posts: 778

09/18/04 - 10:13 AM

OK....now I get it thanks.

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