Prep for USMLEPrep for USMLE
         Forum      |     Resources New Posts   |   Register   |   Login

 AT1 antagonists vs.ACEs  

Post Reply  
  • 0/5
  • 1
  • 2
  • 3
  • 4
  • 5

Author2 Posts

Whats the Main difference in effects?


I believe that no large trials have compared the two and showed differences in clinical outcomes. However, pharmacologically, several differences exist:

ACEi only inhibits ACE-generated angiotensin, and block no other pathways. ARBs are also more potent inhibitors of AT1 signaling when compared to ACEi.
ARBs may also increase AT2 signaling, because they only block AT1. ACEi hinders the breakdown/conversion of many substances including bradykinin which of course give some patients a dry cough.

Bookmark and Share

Login or Register to post messages

show Similar forum topics

Competitive inhibitors/antagonists....
complication of leukotrien antagonists.
show Related resources

Advertise | Support | Privacy | TOS | Premium | Contact