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 Respiratory alkalosis-left shift?  




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Author2 Posts
  #1

Could somebody please explain why in respiratory alkalosis, there is a left shift in the oxygen binding curve??

Whereas, at high altitude,where there occurs resp alkalosis, there is right shift?






  #2

hey i think i can help u with this question.
shift to the right at high altitude is an adaptation. the body is trying to adapt to hyperventilation at high altitude.it does it by increasing the conc of 2-3 bpg.this is in cases of chronic hypoxemia. 2-3 bpg binds to the beta chains of deoxy Hb and decreases the affinity of Hb for oxygen.thus promoting unloading of oxygen causing right shift.
in the other there is no high altitude so no 2 -3 bpg so shift to left!





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